WebJun 1, 2024 · The progress made so far in the elucidation of the structure of free fatty acid receptor 1 (FFAR1) and its secondary and ternary complexes with partial and full allosteric ligands led to the discovery of various putative binding regions on the FFAR1 surface. Attempts to develop FFAR1 agonists culmin … WebDec 3, 2010 · Inducing the overexpression of FFAR1 enhanced the anti-oxidative stress effect of PIO. Similarly, these effects of FFAR1 on PIO were reproduced under conditions of oxidative stress and apoptosis in βTC6 cells that were induced by H 2 O 2. (3) PIO was found to increase the expression of PLCγ, ERK1/2, and PPARγ in lipotoxic β cells.
FFAR1/GPR40: One target, different binding sites, many ... - PubMed
WebThe receptor is strongly activated by gamma-linolenic acid, while myristate gives a lower response. It is also activated by phytanic acid and pristanic acid (PubMed:21570468). Is also activated by synthetic agonists, such as TAK-875 (fasiglifam); this compound is a partial agonist and potentiates the activity of the endogenous ligand gamma-linolenic acid … WebMay 20, 2014 · Furthermore, overexpression of FOXM1 correlated with disease progression and poor prognosis and could serve as an independent predictor of poor … ligonier theonomy
Human FFAR1/beta-Arrestin Stable Cell Line-U2OS - Creative …
WebThis gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided … WebMar 1, 2014 · Inducing FFAR1 overexpression in β cells may support the effect with PIO (Fig. 6 B, C). 3.7. Relationship between the anti-lipotoxic effect of PIO and PLCγ-ERK1/2 … WebFeb 1, 1988 · Inducing the overexpression of FFAR1 enhanced the anti-oxidative stress effect of PIO. Similarly, these effects of FFAR1 on PIO were reproduced under conditions of oxidative stress and apoptosis in βTC6 cells that were induced by H 2 O 2. (3) PIO was found to increase the expression of PLCγ, ERK1/2, and PPARγ in lipotoxic β cells. ligonier theatre pa