WebIdentifying the direct physiological substrates of Cdc14 is an important step in fully understanding its biological functions, both in yeast and other species. Despite its strict … WebOct 30, 2013 · A dual-specificity, paralogue-free Cdc14 phosphatase was located in the nuclei of Beauveria bassiana (filamentous entomopathogen) and functionally …
A Substrate Trapping Method for Identification of Direct Cdc14 ...
WebSep 29, 2024 · 65 specificity it imparts, is a signature feature of Cdc14 enzymes across eukaryotes. The broad conservation 66 implies Cdc14 specificity must fill an essential niche in cellular regulation of most eukaryotic species that 67 cannot be provided by other prominent protein phosphatases. One hypothesis, based on work in the 68 oomycete WebThe Cdc14 dual-specificity phosphatases regulate key events in the eukaryotic cell cycle. However, little is known about the function of mammalian CDC14B family members. Here, we demonstrate that subcellular localization of CDC14B protein is cell cycle regulated. CDC14B can bind, bundle, and stabilize microtubules in vitro independently of its ... radiator\\u0027s k3
Cdc14: a highly conserved family of phosphatases with non …
WebCdc14 is thought to activate DNA replication during the S phase of the cell cycle. We have expressed recombinant Cdc14 in bacteria, demonstrated that it is a dual specificity … WebNov 23, 2011 · In contrast, the phosphatase Cdc14, which counteracts CDK during mitotic exit, showed a higher specificity for the T320S-T347S sensor (Fig. 3H and fig. S3G), which is also in agreement with a ... WebFeb 1, 2007 · The full spectrum of Cdc14 targets remains to be identified, and it is unknown what controls Cdc14 specificity. Cdc14 is sequestered in the nucleolus during most of the cell cycle by the nucleolar ... radiator\\u0027s kd