2024 B-naphthoflavone

B-naphthoflavone

Author: qptm

August undefined, 2024

WebDec 20, 2024 · Beta-naphthoflavone (BNF), a synthetic derivative of a naturally occurring flavonoid, has emerged as a compound of interest in the field of cancer research owing to its substantial potential as a chemopreventive reagent [15]. BNF is a non-carcinogenic agent [16] that protects against tumorigenesis induced by various carcinogens, including 7,12 ... Web2. CYP1A2: 1 of 4 references for b -naphthoflavone used phenacetin. 3. CYP3A4: 2 of 13 references for rifampin and 1 of 3 references for phenobarbital used midazolam. 4. CYP3A4: 1 of the 4 references for dexamethasone used nifedipine. In vivo Table 4. Examples of in vivo substrate, inhibitor, and inducer for specific CYP enzymes for study

B-naphthoflavone induction and its effect on hepatic …

WebC19H12O2. Molecular Weight (g/mol) 272.29. MDL Number. MFCD00004985. InChI Key. VFMMPHCGEFXGIP-UHFFFAOYSA-N. Synonym. alpha-naphthoflavone, 7,8-benzoflavone, 2-phenyl-4h-benzo h chromen-4-one, alpha-naphthylflavone, 2-phenylbenzo h chromen-4-one, benzo h flavone, 4h-naphtho 1,2-b pyran-4-one, 2-phenyl, .alpha. … β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). β-Naphthoflavone is a putative chemopreventive agent. city of sherwood events

5,6-BENZOFLAVONE 6051-87-2 INDOFINE Chemical Company

WebNaphthoflavone. Naphthoflavone may refer to: alpha -Naphthoflavone (7,8-benzoflavone) beta -Naphthoflavone (5,6-benzoflavone) This set index page lists … Webβ-Naphthoflavone has been used: as aryl hydrocarbon receptor agonist to elucidate its effect on Cyp1A1 expression in embryos of transgenic cytochrome P450 1A1 (cyp1a) reporter zebrafish as AhR agonists, to treat primary normal human epidermal keratinocytes (NHEKs) to study about aryl hydrocarbon receptor (AhR) activation by western blot analysis WebWe integrated cellular and molecular biological techniques to examine the effects of beta-naphthoflavone (BNF) exposure in lake trout brain CYP1A distribution and dynamics. … do student loans die with you

(PDF) Biotransformation enzyme activities in the olfactory organ of ...

WebTo examine the effect of DNA methylation on the AhR-mediated pathway, reverse transcription-quantitative PCR analysis was performed. β-naphthoflavone (βNF)-induced CYP1B1 expression was found to be potentiated by pre-treatment of human HepG2 liver cancer cells with 5-aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, but not … WebDec 20, 2024 · In the present study, we examined the therapeutic potential of beta-naphthoflavone (BNF), a synthetic derivative of a naturally occurring flavonoid, in … do student loans follow you after deathWebApr 14, 2024 · Objective: To investigate the dominant metabolic enzymes of six effective components (astragaloside IV, glycyrrhizic acid, calycosin-glucuronide, formononetin, ononin, calycosin-7-O-β-D- glucoside) of Huangqi Liuyi decoction extract (HQD).Methods: Mouse liver microsomes were prepared. The effects of specific inhibitors of CYP450 … do student loans affect credit score

"WebSep 15, 2010 · General Function. Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Specific Function. Cytochromes P450 are a group of heme-thiolate monooxygenases. " - B-naphthoflavone

B-naphthoflavone

WebBifunctional inducers include β-naphthoflavone, which induces both Phase I and Phase II drug-metabolizing enzymes by enhancing the AhR-XRE and Nrf2-ARE axes. Previous … Webβ-Naphthoflavone is an inhibitor for anyl hydrocarbon hydroxylase. We're growing! Check out our job openings! Apply now! The store will not work correctly in the case when …

Did you know?

Webβ-Naphthoflavone has been used: as aryl hydrocarbon receptor agonist to elucidate its effect on Cyp1A1 expression in embryos of transgenic cytochrome P450 1A1 (cyp1a) reporter zebrafish as AhR agonists, to treat primary normal human epidermal keratinocytes (NHEKs) to study about aryl hydrocarbon receptor (AhR) activation by western blot analysis WebBoth fluvoxamine and alpha-naphthoflavone inhibited the metabolism of phenacetin significantly, and the inhibition constants (K(i)) were (5.4+/-1.0) micromol/L and (10.4+/-0.5) micromol/L, respectively. The activity of microsomes pretreated with diphenytriazol for 4 d was similar to that in b-naphthoflavone group, but was significantly ...

Webβ-Naphthoflavone (BNF) is an exogenous ligand for aryl hydrocarbon receptor (AhR) in humans. [ 2] It is an inducer of phase I detoxification enzymes (CYPs) and phase II … WebJan 29, 2015 · 7,8 Benzoflavone is a synthetic flavone derivative, which is a potent aromatase inhibitor. It is known as alpha-naphthoflavone, and it shouldn't be confused with 5,6 benzo, known as, beta-naphthoflavone, which is an inducer of detoxification enzymes and is not an aromatase inhibitor at all. Fig 1. 7,8 Benzoflavone chemical structure.

WebSep 4, 2014 · Cardiac output (a), ventricular heart rate (b), stroke volume (c), and atrioventricular ratio (d) of zebrafish acutely exposed to β-naphthoflavone (BNF). Adult … WebDec 12, 2024 · Radiotherapy induced gastrointestinal syndrome results from the acute damage of intestinal stem cells, impaired crypts reconstruction, and subsequent breakdown of the mucosal barrier. The toxicity of …

WebBiotransformation enzyme activities in the olfactory organ of rainbow trout (Oncorhynchus mykiss). Immunocytochemical localization of cytochrome P4501A1 and its induction by β-naphthoflavone

WebAlso known as b-Naphthoflavone. SMILES: c1ccc(cc1)c2cc(=O)c3c4ccccc4ccc3o2 Pricing. 5 gm @ $55.00. Add to Cart. 10 gm @ $75.00. Add to Cart Bulk Ordering. Request Bulk Quote Material Safety Data Sheet. View Safety Data Sheet Certificate of Analysis. Lot No: 0705048; Lot No: 1212268 do student loans go into my bank accountWebSep 1, 2006 · It has been reported that UGT1A1 is induced by 3-methylcholanthrene and b-naphthoflavone in HepG2 cells (Walle et al., 2000; Walle and Walle, 2002; Hanioka et al., 2006), and suggested that the ... do student loans appear on credit reportWebOct 10, 2011 · However, these enzymes are inducible during prenatal and postnatal stages by prototyope chemicals such as MC or β-naphthoflavone (BNF) (Hakkola et al., 1998). Whereas induction of CYP has been implicated in the potentiation of hyperoxic lung injury ( Hazinski et al. , 1989 ; Hazinski et al. , 1995 ), several groups have shown that CYP1A1 … city of sherwood oregon utility billingWebAug 19, 2004 · Fluorination of the B ring obliterates aromatase inhibition by alpha-naphthoflavone derivatives (AJ2, AJ6, AJ8, and AJ9) or quinolin-4-one derivatives (A2 and A3). Effects of substitutions on the B ring of the synthetic flavones A7, A8, and A9 could not be discerned in our test system because flavone itself was not an inhibitor. city of sherwood oregon mayorWebBackground α-Naphthoflavone (α-NF), also known as 7,8-benzoflavone and 2-phenyl-benzo (h)chromen-4-one, is a synthetic flavone derivative. α-Naphthoflavone is a potent … do student loans go away after 20 yearsWebSep 4, 2014 · Cardiac output (a), ventricular heart rate (b), stroke volume (c), and atrioventricular ratio (d) of zebrafish acutely exposed to β-naphthoflavone (BNF). Adult zebrafish were exposed for 48 h in a static medium to either BNF or solvent control immediately after which cardiac measurements were taken in clean water. city of sherwood orWebDec 12, 2024 · Moreover, the rapid proliferation of IECs is a risk factor for radiation damage. β-naphthoflavone (BNF) is an agonist of the aryl hydrocarbon receptor (AhR) and … city of sherwood library